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It seems probable therefore that in phosphorusnecrosis of the jaw the bone is changed by the phosphorus absorbed andcarried to it by the blood and that this change predisposes to infectionthrough a diseased tooth or sinus. In practice, extrinsic characteristics are themost problematic to deal with, i. Langley has shown thatnicotine group 311nicotine acts on the cell of the perip h eral neuron , safe websites to buy ambien and not on the net-work around it, for the same effect is obtained from the applicationof the poison after the network has degenerated.in the frog nicotine produces fibrillary twitching and slow, pro-longed contraction safe websites to buy ambien of the muscles, which are not prevented by previousdivision of the buy drug zolpidem online europe nerves leading to them, but disappear on the injectionof curara; on the other hand, the paralysis induced by curara may bepartially removed by small quantities of nicotine. 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